Evaluation of 12-lead ECG synthesis using analysis measurements in 240 patients

Synthesis of the 12-lead electrocardiogram (ECG) has been investigated recently as a method for improving patient monitoring in situations where three leads are recorded routinely. The authors present a recent study which analyzes ECG-estimation accuracy by comparing twelve diagnostic parameters from the recorded and synthesized QRS and ST-T segments of 240 patients. The results reveal strong correlations between the synthesized and recorded measurements. These correlations are present for some measurements despite statistically-significant absolute differences between the two sets. Spurious deflections were observed at the beginning of the QRS complex in leads V₁ or V ₃ in a small number of cases. The measurements taken from the Q and R waves in leads V₁ and V₃ indicate that these spurious deflections cause erroneous measurements in about 9 to 17% of the patients