Title :
The Ischemic Heart: What Causes Ectopic Beating?
Author :
Jie, Xiao ; Rodríguez, Blanca ; Trayanova, Natalia
Author_Institution :
Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA
Abstract :
The mechanisms by which spontaneous electrical activity originates in the ischemic heart and leads to arrhythmia remain unknown, however mechanical stretch of the diseased region has been hypothesized to play a role. The goal of this study is to investigate the conditions that favor the initiation of stretch-induced premature beats in the ischemic heart. We employ a mathematical model of the ischemic cell subjected to stretch. The study found that upon stretch, spontaneous beats occur in the ischemic cell, which are due to the stretch-induced re-activation of the L-type calcium current
Keywords :
bioelectric phenomena; biomechanics; biomembrane transport; calcium; cardiology; physiological models; L-type calcium current; arrhythmia; ectopic beating; ischemic cell; ischemic heart; mechanical stretch; spontaneous electrical activity; stretch-induced premature beats; stretch-induced reactivation; Biomedical computing; Biomedical engineering; Biomembranes; Calcium; Equations; Heart rate variability; Ischemic pain; Mathematical model; Myocardium; Rhythm;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616168
