The Ischemic Heart: What Causes Ectopic Beating?

Author

Jie, Xiao ; Rodríguez, Blanca ; Trayanova, Natalia

Author_Institution

Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA

fYear

2006

Firstpage

7194

Lastpage

7197

Abstract

The mechanisms by which spontaneous electrical activity originates in the ischemic heart and leads to arrhythmia remain unknown, however mechanical stretch of the diseased region has been hypothesized to play a role. The goal of this study is to investigate the conditions that favor the initiation of stretch-induced premature beats in the ischemic heart. We employ a mathematical model of the ischemic cell subjected to stretch. The study found that upon stretch, spontaneous beats occur in the ischemic cell, which are due to the stretch-induced re-activation of the L-type calcium current

Keywords

bioelectric phenomena; biomechanics; biomembrane transport; calcium; cardiology; physiological models; L-type calcium current; arrhythmia; ectopic beating; ischemic cell; ischemic heart; mechanical stretch; spontaneous electrical activity; stretch-induced premature beats; stretch-induced reactivation; Biomedical computing; Biomedical engineering; Biomembranes; Calcium; Equations; Heart rate variability; Ischemic pain; Mathematical model; Myocardium; Rhythm;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1616168

Filename

1616168