Title :
Implementation, performance and characterization of the DiFrancesco-Noble model
Author :
Cabo, Candido ; Papazoglou, Alexandra A. ; Barr, Roger C.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
The authors describe their experience in the implementation and the use of the DiFrancesco-Noble model. Clarifying references for the equations are given as well as a way to implement the equations in a propagation model. An estimate of the number of floating point operations required is given as well as the running times of functional programs in some widely used computers. A number of parameters useful in the design of numerical experiments like resting membrane resistance are also given. A short discussion on the accuracy of the equations for the fast sodium current is also included as well as some modifications made to the DiFrancesco-Noble equations, so that the depolarization rate was closer to real tissue experiments
Keywords :
bioelectric phenomena; biology computing; cardiology; digital simulation; physiological models; DiFrancesco-Noble model; computer running time; depolarization rate; equations accuracy; fast Na+ current; floating point operations; functional programs; numerical experiments; propagation model; resting membrane resistance; Biomedical engineering; Biomembranes; Clamps; Differential equations; Heart; Mathematical model; Optical fiber polarization; Steady-state; Uncertainty; Voltage;
Conference_Titel :
Computers in Cardiology 1992, Proceedings of
Conference_Location :
Durham, NC
Print_ISBN :
0-8186-3552-5
DOI :
10.1109/CIC.1992.269546
