Title :
A CMOS optical/potential image sensor with 7.5 μm pixel size for on-chip neural and DNA spot sensing
Author :
Tokuda, T. ; Ng, D.C. ; Yamamoto, A. ; Kagawa, K. ; Nunoshita, M. ; Ohta, J.
Author_Institution :
Graduate Sch. of Mater. Sci., Nara Inst. of Sci. & Tech.
Abstract :
An optical/potential CMOS image sensor was designed and fabricated for bioimaging applications. The image sensor is capable to simultaneously sense an optical image and an on-chip potential image. Target applications of the sensor are on-chip (optical + potential) neural imaging and on-chip DNA microarray sensing. The sensor has a QCIF (176 times 144) pixel array with alternatively aligned optical/potential sensing pixels. The pixel size is 7.5 mum times 7.5 mum. The potential resolution is confirmed to be better than 10 mV. An on-chip fluorescence imaging of a mouse´s hippocampus was performed to demonstrate that fluorescence imaging is possible with on-chip configuration
Keywords :
CMOS image sensors; DNA; bioelectric potentials; biomedical optical imaging; brain; electric sensing devices; fluorescence; molecular biophysics; neurophysiology; optical sensors; CMOS; DNA spot sensing; bioimaging applications; mouse hippocampus; on-chip DNA microarray sensing; on-chip fluorescence imaging; on-chip neural imaging; optical image sensor; potential image sensor; Biomedical optical imaging; Biosensors; CMOS image sensors; DNA; Image sensors; Optical arrays; Optical imaging; Optical sensors; Pixel; Sensor arrays;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616189
