Development of stable and tunable high-speed liquid jets in microscale for miniaturized and disposable flow cytometry

Author

Huh, Dongeun ; Wei, Hsien-Hung ; Grotberg, James B. ; Takayama, Shuichi

Author_Institution

Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA

fYear

2002

fDate

6/24/1905 12:00:00 AM

Firstpage

449

Lastpage

452

Abstract

Presents an experimental investigation of the stability phenomena of an air-liquid two-phase microfluidic system in air-sheath-driven flow cytometry. High-speed thin liquid jets interacting with air-sheath flows and polymeric microfluidic channel walls show different flow behaviors in response to channel geometry, surface chemistry, and flow rates of liquid and air. We studied the variation of flow structure and stability of liquid jets in hydrophobic channels having different thickness to identify the effect of device geometry on microscale air-liquid two-phase flows

Keywords

biological techniques; cellular biophysics; channel flow; jets; microfluidics; two-phase flow; air flow rates; air-liquid two-phase microfluidic system; air-sheath flows; air-sheath-driven flow cytometry; channel geometry; device geometry; flow structure; high-speed thin liquid jets; hydrophobic channels; liquid flow rates; microfluidic systems; microscale; microscale air-liquid two-phase flows; miniaturized disposable flow cytometry; polymeric microfluidic channel walls; stability phenomena; stable tunable high-speed liquid jets; surface chemistry; Biomedical engineering; Chemistry; Costs; Fluid flow; Geometry; Microfluidics; Polymers; Shape; Size control; Stability;

fLanguage

English

Publisher

ieee

Conference_Titel

Microtechnologies in Medicine & Biology 2nd Annual International IEEE-EMB Special Topic Conference on

Conference_Location

Madison, WI

Print_ISBN

0-7803-7480-0

Type

conf

DOI

10.1109/MMB.2002.1002368

Filename

1002368