Title :
Role of Sphingosine Kinase in the Expression of Adhesion Molecules on Monocytes Induced by Tumor Necrosis Factor-Alpha (Relevant to Atherosclerosis)
Author :
Yan, Tuang Chew ; Liang, Zhong ; Alirio, Melendez J. ; Sankaranarayanan, Meena ; Ghista, Dhanjoo N.
Author_Institution :
Sch. of Chem. & Biomed. Eng., Nanyang Technol. Univ.
Abstract :
TNFalpha stimulates SPHK in the monocyte, which leads to the expression of adhesion molecules on the cell surface. The adhesion of leukocytes to the endothelium is one of the early stages of the onset of atherosclerosis. In this paper, we have delineated the TNFalpha-induced and SPHK-dependent signaling pathway. In addition, we have developed a biomathematical model to qualify the SPHK time-dependent activity at a specific site in the cell upon TNFalpha stimulation. Thus, this study provides a biochemical and mechanistic approaches to the understanding of leukocyte-endothelial attachment, so that measures could be designed to minimize the onset of atherosclerosis
Keywords :
adhesion; biochemistry; blood; cellular biophysics; enzymes; molecular biophysics; physiological models; tumours; SPHK time-dependent activity; SPHK-dependent signaling pathway; TNFalpha; adhesion molecule expression; atherosclerosis; biochemistry; biomathematical model; cell surface; endothelium; leukocyte-endothelial attachment; leukocytes; mechanistic approaches; monocytes; sphingosine kinase; tumor necrosis factor-alpha; Adhesives; Atherosclerosis; Biomedical engineering; Biomembranes; Chemical technology; Educational institutions; Lesions; Neoplasms; Recruitment; White blood cells;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616344
