Title :
On the Alignment Space
Author :
Shen, Shi-Yi ; Wang, Kui ; Hu, Gang ; Chen, Lu-Sheng ; Zhang, Hua ; Xia, Shu-Tao
Author_Institution :
Nankai Univ., Tianjin
Abstract :
Sequences with generalized errors which are called mutations in bioinformatics and generalized error-correcting codes are studied in this paper. In the areas of bioinformatics, computer science and information theory, sequences with generalized errors are discussed respectively for different aims. First, we give the definitions of alignment distance and Levenshtein distance by expansion sequences and discuss their properties and relations. Then the modular structure theory is introduced for strictly describe the expansion sequences. We show that the expansion modular structures of sequences form a Boolean algebra. As applications of the modular structure theory, we give a new and more strict proof of triangle inequality for alignment distance. At last, the definition and construction of generalized error-correcting codes are studied, and some optimal codes with small length are listed
Keywords :
Boolean algebra; biocomputing; computer science; error correction codes; Boolean algebra; DNA computing; Levenshtein distance; alignment distance; alignment space; bioinformatics; expansion sequences; generalized error-correcting codes; generalized errors; modular structure theory; mutations; sequences; Bioinformatics; Boolean algebra; Computer errors; DNA computing; Error correction; Error correction codes; Genetic communication; Genetic mutations; Information theory; Sequences;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616389