Functional Imaging: Dynamic Contrast-Enhanced CT using a Distributed-Parameter Physiologic Model for Accessing Stroke and Intracranial Tumor

Functional imaging has the potential to be a practical and widely-available method of studying the pathophysiology of disease using modern CT and MRI technologies. With the high temporal resolution achievable by these technologies, a two-compartment distributed-parameter model, which more accurate represents the tracer concentration within the vascular space, was applied on two patients´ data with intracranial tumor and stroke. The parametric maps successfully generated were more informative than the current commercial software packages and the commonly used lumped-parameter compartmental models