Title :
A multiscale model for the selection process of ovulatory follicles
Author :
Echenim, Nki ; Sorine, Michel ; Clément, Frédérique
Author_Institution :
Unit´´e de Recherche, INRIA Rocquencourt, Le Chesnay
Abstract :
The biological meaning of follicular development is to free fertilizable oocytes at the time of ovulation. The selection of ovulatory follicles in mammal ovaries is an FSH-dependent selection process. In this paper, we design a multi-scale model of follicular development, where selection arises from the feedback between the ovaries and the pituitary gland and appeals to control theory concepts. Each ovarian follicle is characterized by a 2D density function giving an age and maturity-structured description of its cell population. The control intervenes in the velocity and loss terms of the conservation law ruling the changes in the density. The numerical outputs of the model, integrated with the finite volume method, are consistent with physiological knowledge
Keywords :
cellular biophysics; physiological models; 2D density function; FSH-dependent selection process; cell population; conservation law; control theory concepts; fertilizable oocytes; finite volume method; follicle stimulating hormone; follicular development; mammal ovaries; multiscale model; ovulation; ovulatory follicles; physiological knowledge; pituitary gland; Biochemistry; Biological system modeling; Cells (biology); Control theory; Density functional theory; Finite volume methods; Mathematical model; Negative feedback; Pituitary gland; Velocity control;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616406
