Title :
Simulation Study of Transmural Cellular Electrical Properties in Failed Human Heart
Author :
Zhang, Yu ; Shou, Guofa ; Xia, Ling
Author_Institution :
Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou
Abstract :
This paper presents simulation study of the action potential waveforms of different ventricular cell types based on experimental studies of transmural electrophysiological heterogeneities in control and failing human hearts. The results show that prolonged action potential duration (APD) and APD rate-adaptation are markedly transmural heterogeneous in heart failure than those in controlled heart which may be due to enhanced transmural heterogeneities of ICaL and I ks in myocytes. This mathematical model of the failed heart cellular action potential may also serve as a paradigm for studying the failed heart´s mechanical properties with excitation-contraction coupling
Keywords :
bioelectric potentials; cardiology; cellular biophysics; physiological models; APD rate-adaptation; action potential waveforms; excitation-contraction coupling; failed human heart; myocytes; prolonged action potential duration; transmural cellular electrical properties; transmural electrophysiological heterogeneities; ventricular cell types; Biomedical engineering; Biomembranes; Calcium; Computer simulation; Hafnium; Heart; Humans; Mathematical model; Mechanical factors; Shape control; cellular electrophysilolgy; heart failure; mathematical model; simulation;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616413
