Modeling Cardiac Activation and the Impact of a Discontinuous Myocardium

Methods have been developed for modeling cardiac activation which accounts for detailed myocardial geometric structures derived from specific tissue samples. This modeling allows both study and analysis of the effects of cleavage planes and other structural barriers to myocardial current flow. Specialized numerical and computational procedures have been developed to enable this modeling. The results that have been obtained clearly show the impact that discontinuities have in the formation of transmural virtual sources and also assist in better understanding experimental recordings. We are continuing to increase our capacity for modeling larger tissue samples, particularly those capable of sustaining reentry