Effect of prolonged pressure on flowmotion: An Investigation Using an in vivo Rat Model

Author

Li, Zengyong ; Tam, Eric W C ; Kwan, Maggie P C ; Mak, Arthur F T ; Lo, Samuel C L ; Leung, Mason C P

fYear

2006

Firstpage

597

Lastpage

600

Abstract

The objectives of this study is to assess the effect of prolonged loading on the skin blood flowmotion in rats as measured by laser Doppler flowmetry (LDF) using wavelets transform and power spectral in the rat skin microcirculation. External pressure of 13.3kPa (100 mmHg) was applied to the trochanter area and the distal lateral tibia of Sprague-Dawley rats via two specifically designed pneumatic indentors. The loading duration was 6 hours/day for 4 consecutive days. The results showed that 1) spontaneous rhythmic activities were present in skin blood flow of anesthetized rats, 2) significant decrease of flowmotion power (p=0.023 for trochanter and p=0.043 for tibia) was found in the frequency range of 0.01-0.04Hz after prolonged loading. Our results suggested that reduced vasomotion in the frequency of 0.01-0.04 Hz might be involved in the mechanisms leading to pressure ulcer formation

Keywords

Doppler measurement; bone; haemorheology; skin; wavelet transforms; 0.01 to 0.04 Hz; 100 mmHg; 13.3 kPa; 4 day; 6 hour; Sprague-Dawley rats; distal lateral tibia; in vivo rat model; laser Doppler flowmetry; pneumatic indentors; power spectra; pressure ulcer formation; prolonged pressure effect; rat skin microcirculation; skin blood flowmotion; spontaneous rhythmic activities; trochanter area; vasomotion; wavelets transform; Blood; Frequency; In vivo; Laser modes; Measurement by laser beam; Power lasers; Power measurement; Rats; Skin; Wavelet transforms; Pressure ulcer; flowmotion/vasomotion; prolonged loading; skin microcirculation; wavelets transform;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1616483

Filename

1616483