Fabrication of gating nanopore towards single-biomolecule electrical identification

We developed a simple fabrication method for a gating nanopore nanostructure, which is composed of a solid-state nanopore and embodied nanogap-electrode inside the nanopore. The method by using deep reactive-ion etching technique achieved a high-yield rate and easily controlled the pore-length for the gating nanopore device. In addition, by using the gating nanopore, we investigated single-particles / biomolecules that pass through a nanopore only by change in electric current not only flowing parallel to a nanopore, but also flowing between nanogap electrodes perpendicular to the nanopore. From the ionic current intensity and its time profiles, we identify a sample single-particles/bioanalytes. The electrical measurement by using gating nanopore would be a promising methodology for single-biomolecule sensors.