The preliminary study of antiproliferative effect on MCF-7 cells of Rhodiola algida Var. tangutica

Author

Lu, Dianxiang ; Zhang, Shu-na ; Ge, Rili ; Lu, Dianjun

Author_Institution

Res. Center for High Altitude Med., Qinghai Univ., Xining, China

fYear

2011

Firstpage

23

Lastpage

25

Abstract

The anti-tumor effect of Rhodiola algida Var. tangutica in vitro was researched in this article. HPLC analysis of the aqueous extract defined the presence of salidroside and tyrosol. The results of MTT assay showed that the extract reduces survival of MCF-7 tumor cells markedly. Microscopic observation confirmed the apoptosis of the tumor cells after being treated by the extract. Some cells containing vacuoles and apoptotic bodies were observed. The FCM analysis showed that lower concentrations of the extract caused much apoptotic cells and higher concentrations led to much necrotic cells.

Keywords

botany; cellular biophysics; patient treatment; tumours; FCM analysis; HPLC analysis; MCF-7 cells; MTT assay; Rhodiola algida Var. tangutica; antiproliferative effect; antitumor effect; apoptosis; extract; necrotic cells; salidroside; tumor cells; tyrosol; vacuoles; Microscopy; MCF-7 cells; Rhodiola algida Var. tangutica; anti-tumor; apoptosis;

fLanguage

English

Publisher

ieee

Conference_Titel

Complex Medical Engineering (CME), 2011 IEEE/ICME International Conference on

Conference_Location

Harbin Heilongjiang

Print_ISBN

978-1-4244-9323-4

Type

conf

DOI

10.1109/ICCME.2011.5876698

Filename

5876698