Theory and Experiments of MEMS Thermal Biosensors

Author

Wang, Li ; Lin, Qiao

Author_Institution

Dept. of Mech. Eng., Carnegie Mellon Univ., Pittsburgh, PA

fYear

2005

fDate

6/27/1905 12:00:00 AM

Firstpage

1301

Lastpage

1304

Abstract

This paper presents a theoretical and experimental investigation of MEMS thermal biosensors in flow-through measurements of metabolites. A model is developed to consider convective heat transfer effects and enzyme kinetics using the Michaelis-Menton theory. Numerical solutions from the model are compared with experimental data obtained from a prototype MEMS thermal biosensor. Satisfactory agreement is found between the theoretical and experimental results, indicating that the model is useful for designing MEMS thermal biosensors with optimized performance

Keywords

bioMEMS; biochemistry; biosensors; biothermics; convection; enzymes; microfluidics; microsensors; molecular biophysics; temperature sensors; MEMS thermal biosensors; Michaelis-Menton theory; convective heat transfer effects; enzyme kinetics; flow-through measurements; metabolites; Biochemistry; Biomembranes; Biosensors; Heat transfer; Kinetic theory; Mechanical engineering; Micromechanical devices; Semiconductor device measurement; Sugar; Thermal conductivity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the

Conference_Location

Shanghai

Print_ISBN

0-7803-8741-4

Type

conf

DOI

10.1109/IEMBS.2005.1616665

Filename

1616665