Title :
Quantitation of Renal Function Based on Two-Compartmental Modeling of Renal Pelvis
Author :
Meng, Loh Kah ; Ng, David ; Ghista, Dhanjoo N. ; Rudolph, Heiko
Author_Institution :
Sch. of Eng., Nanyang Polytech
Abstract :
The primary functions of the kidney are: (i) to get rid of the body waste materials that are either ingested or produced by metabolism, and (ii) to control the volume and composition of the body fluids. Herein, we provide a noninvasive methodology to assess physiological function of the kidneys. For this purpose, we analyze the renograms with 2-compartmental modelling of the kidney-renal outflow system, and therefrom compute the amount of flow of renal radionuclide into and out of the renal pelvis compartment. The derived information of uptake (k/A) and washout (e(beta/2V2)t sinhAt) rates can be of considerable use. The paper provides a number of case studies for the verification of the derived system governing equations against clinical renograms
Keywords :
haemodynamics; kidney; physiological models; body fluid composition; body fluid volume; body waste materials; kidney-renal outflow system; metabolism; renal function; renal pelvis; renal radionuclide; renograms; two-compartmental modeling; Biochemistry; Biomedical engineering; Differential equations; Filtering; Filtration; Mathematical model; Pelvis; TV; Waste materials; Weight control; GFR; Renal outflow obstruction; glomerular filtration rate; renal function;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1616937
