Adaptive Left Ventricular Ejection Time Estimation Using Multiple Peripheral Pressure Waveforms

An adaptive approach is proposed for the problem of left ventricular ejection time (LVET) estimation using peripheral pressure waveform signals. The proposed algorithm, which makes use of 2 peripheral pressure measurements, makes it possible to adaptively estimate the LVET in response to different cardiovascular physiologic states. The algorithm builds on features obtained from global and branch-specific characterization of the cardiovascular circulation as well as waveform features to dramatically improve the accuracy of LVET estimation. The performance of the proposed approach is evaluated with respect to its heart-rate-based conventional counterpart, which shows approximately 40% improvement of estimation accuracy in terms of R² values from 0.6655 for the conventional waveform-based approach to 0.9222 for the proposed approach