The simulation of intracranial pressure dynamics

Intracranial pressure (ICP) research has significant importance in clinic. There are many internal or external factors which cause the vibration of ICP, including heart beat, breath, neural regulation, and so on. A lumped parameter mathematical model of ICP dynamics is established based on animal (dogs) experiments, which includes cerebrovascular bed, cerebrospinal fluid (CSF) formation and absorption, brain compliance, lumbar cerebrospinal fluid, and interactions between these factors. An exponential volume-pressure relationship is employed in this simulation to describe cerebrovascular compliance. The model well simulates intracranial pressure dynamics and the vibration of ICP when compared to animal experiments; the changes of parameters in simulation are consistent with animal experiments. It offers certain values for clinical ICP ward and diagnosis