Title :
Transcutaneous Fluorescent Imaging with a Depth-Dependent Point Spread Function
Author :
Shimizu, Koichi ; Tochio, Koji ; Kato, Yuji
Author_Institution :
Graduate Sch. of Information Sci. & Technol., Hokkaido Univ., Sapporo
Abstract :
The transcutaneous fluorescent imaging (TFI) method was applied to the imaging of a small experimental animal such as a rat. The feasibility of the functional imaging in TFI was verified. To make this method more practical, a technique of scattering suppression was proposed. The depth-dependent PSF was derived as an analytical solution in a closed form. The applicability of this technique to the functional TFI and its usefulness were demonstrated in animal experiments
Keywords :
biomedical optical imaging; fluorescence; light scattering; medical image processing; optical transfer function; depth-dependent point spread function; functional imaging; rat; scattering suppression; small animal imaging; transcutaneous fluorescent imaging; Animals; Fluorescence; Geometry; Light scattering; Noninvasive treatment; Optical imaging; Optical reflection; Optical scattering; Optical surface waves; Tomography;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1617141
