DocumentCode :
1622444
Title :
Dynamic-average Characteristics of Late Wave of Auditory Evoked Potentials for Synaptic Malfunction Rat Model
Author :
Han, L.Y. ; Tian, X.
Author_Institution :
Dept. of Biomed. Eng., Tianjin Med. Univ.
fYear :
2006
Firstpage :
3664
Lastpage :
3667
Abstract :
The aim of this study is to investigate dynamic characteristics of late wave of auditory evoked potentials (AEPs) in synaptic malfunction rat model. Two dynamic characteristics relative to cognitive function were investigated which are dynamic latency and dynamic amplitude of P1. Synaptic malfunction model was made by Sprague-Dawley rats via microinjecting beta-amyloid protein (A-beta) into hippocampal CA1 area of rat. Dynamic AEPs with high background noise were recorded for both model and normal rats in experiments. Dynamic late wave were taken from dynamic AEPs using third-order correlation and wavelet technology. The dynamic-average latency and the dynamic-average amplitude of P1 in a small time window (5s) were performed as dynamic index in this study, which remain most of dynamic information because the average window was very small. Then dynamic-average latency and the dynamic-average latency of P1 were compared between synaptic malfunction rat and normal group. The results of this study have demonstrated that: (1) the dynamic-average latency of P1 for model rats prolonged remarkably than control (P<0.01, alpha =0.05); (2) the dynamic-average amplitude of P1 for model rats increased remarkably than control(P<0.01,alpha =0.05). The conclusion is that dynamic-average latency and dynamic-average amplitude in the synaptic malfunction rats model has obvious difference with normal group
Keywords :
auditory evoked potentials; brain; cognition; molecular biophysics; noise; proteins; 5 s; Sprague-Dawley rats; auditory evoked potentials; cognitive function; dynamic-average amplitude; dynamic-average characteristics; dynamic-average latency; hippocampal CA1 area; late wave; microinjecting beta-amyloid protein; synaptic malfunction rat model; Aging; Alzheimer´s disease; Background noise; Biomedical engineering; Delay; Dementia; Microinjection; Proteins; Rats; Signal processing; amplitude; dynamic late wave of AEPs; latency; rat model; synaptic malfunction;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
Type :
conf
DOI :
10.1109/IEMBS.2005.1617277
Filename :
1617277
Link To Document :
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