Title :
A physiologic-based circuit model of excitation and inhibition in the postsynaptic neuron
Author :
Levine, Michael D. ; Eisenberg, Marvin F. ; Fare, Thomas L.
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., George Washington Univ., Washington, DC, USA
Abstract :
A metal-oxide-semiconductor field-effect transistor (MOSFET) represents the variable conductance of transmitter-gated ion channels in the input (or postsynaptic) region of the neuron. The MOSFET is incorporated into a circuit model of the postsynaptic membrane. Simulation of the circuit yields an output representing the membrane potential of the input region. Simulation is performed for the excitatory, inhibitory and combined excitatory-inhibitory states
Keywords :
cellular biophysics; insulated gate field effect transistors; neural nets; neurophysiology; physiological models; MOSFET; circuit model; combined excitatory-inhibitory states; excitation; inhibition; membrane potential; physiologic-based circuit model; postsynaptic neuron; transmitter-gated ion channels; variable conductance; Biomembranes; Capacitance; Circuit simulation; Lipidomics; MOSFET circuits; Neurons; Predictive models; SPICE; Transmitters; Voltage control;
Conference_Titel :
Circuits and Systems, 1992., Proceedings of the 35th Midwest Symposium on
Conference_Location :
Washington, DC
Print_ISBN :
0-7803-0510-8
DOI :
10.1109/MWSCAS.1992.271383
