Systemic alternation of depolarization sites in the postsynaptic membrane: a biomathematical model

We propose a preliminary mathematical model and simulation of temporally and spatially patterned alternation of postsynaptic depolarization sites as a hypothetical function of structural changes in the target neuron biomembrane. Our model demonstrates that observed state changes in a target neuron are not only a function of phase relationships among excitatory and inhibitory inputs but of where within the cell the last action potential was initiated. Neurobiological evidence indicates that the observed changes may be a function of altered molecular positions and orientation within the target membrane lattice. We conclude with a brief discussion of the possible role of the system in the regulation of electrical signals.