Title :
Numerical study on a layered fractional model of drug release
Author :
Li, Xicheng ; Chen, Wen
Author_Institution :
Dept. of Eng. Mech., Hohai Univ., Nanjing, China
Abstract :
A layered model describing the drug delivery from polymeric coating into arteries after stenting procedures is developed. By the aid of the numerical technique, the effects of the order of the fractional derivative and the permeability of the membrane are examined. The results show that the order of the fractional derivative and the permeability affect the diffusion process in different ways. It can be used to study the effect of different coating parameters and configurations on the drug release.
Keywords :
biodiffusion; biomedical materials; biomembrane transport; blood vessels; drugs; numerical analysis; permeability; physiological models; polymer films; stents; arteries; diffusion process; drug delivery; drug release; layered fractional model; numerical study; polymeric coating; stenting procedure; Equations; Polymers;
Conference_Titel :
Mechatronics and Embedded Systems and Applications (MESA), 2010 IEEE/ASME International Conference on
Conference_Location :
Qingdao
Print_ISBN :
978-1-4244-7101-0
DOI :
10.1109/MESA.2010.5551997
