Title :
A novel apparatus for the volume estimation of in vitro thrombus growth
Author :
Affanni, A. ; Specogna, Ruben ; Trevisan, F.
Author_Institution :
Dept. of Electr., Mech. & Manage. Eng., Univ. of Udine, Udine, Italy
Abstract :
Current available diagnostic technologies for the analysis of thrombus formation fail to detect the thrombus volume and are unable to capture the kinetics of the overall process. In the paper, we present a novel methodology, based on the fusion of electrical and optical data, to measure in real time the volume and the geometry of platelet thrombus growth in an artificial microchannel, where whole blood flows on the surface of a thrombogenic substrate.
Keywords :
biomedical measurement; blood; cellular biophysics; electric impedance imaging; medical computing; medical image processing; microsensors; substrates; artificial microchannel; blood; diagnostic technologies; electrical data; in vitro thrombus growth; kinetics; optical data; platelet thrombus growth; thrombogenic substrate; thrombus formation; thrombus volume; volume estimation; Blood; Electrodes; Impedance; Impedance measurement; Microchannel; Microscopy; Optical imaging; Electrical Impedance Spectroscopy; whole blood hemostasis;
Conference_Titel :
Microelectronic Test Structures (ICMTS), 2014 International Conference on
Conference_Location :
Udine
Print_ISBN :
978-1-4799-2193-5
DOI :
10.1109/ICMTS.2014.6841472
