A novel apparatus for the volume estimation of in vitro thrombus growth

Author

Affanni, A. ; Specogna, Ruben ; Trevisan, F.

Author_Institution

Dept. of Electr., Mech. & Manage. Eng., Univ. of Udine, Udine, Italy

fYear

2014

fDate

24-27 March 2014

Firstpage

83

Lastpage

86

Abstract

Current available diagnostic technologies for the analysis of thrombus formation fail to detect the thrombus volume and are unable to capture the kinetics of the overall process. In the paper, we present a novel methodology, based on the fusion of electrical and optical data, to measure in real time the volume and the geometry of platelet thrombus growth in an artificial microchannel, where whole blood flows on the surface of a thrombogenic substrate.

Keywords

biomedical measurement; blood; cellular biophysics; electric impedance imaging; medical computing; medical image processing; microsensors; substrates; artificial microchannel; blood; diagnostic technologies; electrical data; in vitro thrombus growth; kinetics; optical data; platelet thrombus growth; thrombogenic substrate; thrombus formation; thrombus volume; volume estimation; Blood; Electrodes; Impedance; Impedance measurement; Microchannel; Microscopy; Optical imaging; Electrical Impedance Spectroscopy; whole blood hemostasis;

fLanguage

English

Publisher

ieee

Conference_Titel

Microelectronic Test Structures (ICMTS), 2014 International Conference on

Conference_Location

Udine

ISSN

1071-9032

Print_ISBN

978-1-4799-2193-5

Type

conf

DOI

10.1109/ICMTS.2014.6841472

Filename

6841472