Title :
Motifs in regulatory networks and their structural robustness
Author :
Elena, A. ; Ben-Amor, H. ; Glade, N. ; Demongeot, J.
Author_Institution :
TIMC-IMAG, Univ. J. Fourier, Grenoble
Abstract :
If we consider the regulatory networks used in systems biology (especially in neural and genetic networks), we observe certain regularities in their architecture, namely the occurrence of interaction motifs, i.e. of oriented sub-graphs relating their elements with the same interaction scheme. We propose here to describe some of these motifs we can consider as universal because they are often met in the regulatory networks architecture, and to study their main robustness properties (called also structural stability), i.e. their ability to keep after topological or dynamical perturbations, their essential asymptotic features, as their attractors number, shape and behaviour, like their periodicity.
Keywords :
cellular biophysics; genetics; network theory (graphs); network topology; neural nets; neurophysiology; attractor number; genetic regulatory networks; interaction motifs; network architecture; network asymptotic features; network behaviour; network dynamical perturbations; network motif structure robustness; network periodicity; network shape; network structural stability; network topological perturbations; neural networks; oriented subgraphs; regulatory network motif; systems biology; Electronic mail; Genetic expression; Jacobian matrices; Neurons; Organisms; Robust stability; Robustness; Shape; Structural engineering; Systems biology; attractors; interaction motifs; periodicity; regulatory networks; robustness; structural stability;
Conference_Titel :
BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
Conference_Location :
Athens
Print_ISBN :
978-1-4244-2844-1
Electronic_ISBN :
978-1-4244-2845-8
DOI :
10.1109/BIBE.2008.4696699