Title :
Use of Gene Ontology semantic information in protein interaction data visualization
Author :
Massanet, Raimon ; Caminal, Pere ; Perera, Alexandre
Author_Institution :
ESAII Dept., Tech. Univ. of Catalonia, Barcelona
Abstract :
The Gene Ontology project is an effort to structure knowledge on biological products and processes by adding semantic information to them. This is done in a systematic way so that this additional information can be automatically processed. In this contribution a protein-protein interaction visualization algorithm is proposed, which combines protein interaction data with Gene Ontology semantic information. The information is integrated using a semantic distance measure defined in ontologies or taxonomies. Multidimensional scaling is applied to this measure and the output complements protein interaction data in building an interaction visualization map.
Keywords :
biology computing; data visualisation; information services; knowledge engineering; ontologies (artificial intelligence); proteomics; vocabulary; Gene Ontology project; Gene Ontology semantic information; biological knowledge structuring; information integration; multidimensional scaling; protein interaction data visualization; protein interaction visualization map; protein-protein interaction visualization algorithm; semantic distance measure; taxonomies; Bioinformatics; Biological information theory; Chemicals; Data visualization; Genetics; Genomics; Humans; Ontologies; Proteins; Proteomics;
Conference_Titel :
BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on
Conference_Location :
Athens
Print_ISBN :
978-1-4244-2844-1
Electronic_ISBN :
978-1-4244-2845-8
DOI :
10.1109/BIBE.2008.4696741
