A computer simulation model of gene replacement in vector populations

Author

Guevara, Mauricio ; Vallejo, Edgar E.

Author_Institution

Comput. Sci. Dept., ITESM, Zaragoza

fYear

2008

Firstpage

1

Lastpage

6

Abstract

In this paper, we conduct a series of computer simulations on the genetic modification of disease vectors. In our model, a population of mosquitoes is modeled as DNA sequences. A gene drive mechanism based on simulated transposable elements is inserted into DNA sequences to confer immunity to individuals. Different scenarios on the spread and prevalence of modified genes are simulated using the evolutionary game theory. Preliminary results suggest that the proposed model could be useful for identifying a set of population-level conditions that a disease control strategy based on genetic modification of vectors should satisfy to be effective.

Keywords

DNA; bioinformatics; diseases; game theory; genetics; molecular biophysics; DNA sequence; disease control strategy; disease vectors; evolutionary game theory; gene drive mechanism; gene replacement; genetic modification; modified gene prevalence; modified gene spread; mosquitoes; vector population; Capacitive sensors; Computational modeling; Computer simulation; DNA; Game theory; Genetics; Immune system; Parasitic diseases; Sequences; Strain control;

fLanguage

English

Publisher

ieee

Conference_Titel

BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on

Conference_Location

Athens

Print_ISBN

978-1-4244-2844-1

Electronic_ISBN

978-1-4244-2845-8

Type

conf

DOI

10.1109/BIBE.2008.4696743

Filename

4696743