Title :
Chemical bionics - a novel design approach using Ion Sensitive Field Effect Transistors
Author :
Georgiou, Pantelis ; Toumazou, Chris
Author_Institution :
Inst. of Biomed. Eng., Imperial Coll. London, London
Abstract :
This paper introduces Chemical Bionics in which the biochemical physiology of cells in the body are implemented in VLSI to make novel bio-inspired therapeutic devices. As an example, the glucose dependant electrophysiology of the pancreatic beta cell is implemented in silicon to form a novel bio-inspired prosthetic for glucose homeostasis of Type I diabetes. For this, the Ion Sensitive Field Effect Transistor (ISFET) is shown as a suitable chemical sensing front end, which allows CMOS monolithic implementation, as well as low power weak-inversion operation.
Keywords :
CMOS integrated circuits; VLSI; biochemistry; bioelectric potentials; biological organs; biomedical electronics; biomedical equipment; biosensors; cellular biophysics; chemical sensors; diseases; integrated circuit design; ion sensitive field effect transistors; low-power electronics; prosthetics; silicon; CMOS chemical sensor; CMOS monolithic implementation; ISFET; Si; bio-inspired prosthetics; bio-inspired therapeutic device; biochemical VLSI; biochemical physiology; chemical bionics; chemical sensing front end; glucose dependant electrophysiology; glucose homeostasis; ion sensitive field effect transistor; low power weak-inversion operation; pancreatic beta cell; silicon metabolic cells; type I diabetes; Biosensors; Chemical sensors; Chemical technology; FETs; Humans; Neurons; Pancreas; Silicon; Sugar; Very large scale integration;
Conference_Titel :
Biomedical Circuits and Systems Conference, 2008. BioCAS 2008. IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4244-2878-6
Electronic_ISBN :
978-1-4244-2879-3
DOI :
10.1109/BIOCAS.2008.4696916
