Measuring the impedance of a tethered bilayer membrane biosensor

Author

Hamilton, Tara J. ; Van Schaik, André ; Cornell, Bruce

Author_Institution

Sch. of Inf. Technol. & Electr. Eng., Univ. of Queensland, Brisbane, QLD

fYear

2008

Firstpage

361

Lastpage

364

Abstract

In this paper we present a method for measuring the complex impedance of a tethered bilayer membrane (tBLM). Measuring the impedance of a tBLM can involve large, nonportable, expensive instrumentation. Here we present a method of complex impedance measurement that is portable and inexpensive; requiring only a laptop or palm-pocket computer with a USB interface. The complex impedance measurement is improved by using a type of pseudorandom binary sequence (PRBS) called a maximum length sequence (MLS). This method of impedance measurement improves the resolution over conventional sinusoidal frequency sweeping methods.

Keywords

binary sequences; bioelectric phenomena; biological techniques; biology computing; biomembranes; biosensors; computerised instrumentation; electric impedance measurement; lipid bilayers; random sequences; system buses; USB interface; electric impedance measurement; laptop computer; lipid bilayer membrane; maximum length sequence; palm-pocket computer; pseudorandom binary sequence; sinusoidal frequency sweeping method; tethered bilayer membrane biosensor; Binary sequences; Biomembranes; Biosensors; Computer interfaces; Frequency; Impedance measurement; Instruments; Multilevel systems; Portable computers; Universal Serial Bus; biosensor; complex impedance; maximum length sequence (MLS); pseudorandom binary sequence (PRBS); tethered bilayer membrane (tBLM);

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference, 2008. BioCAS 2008. IEEE

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4244-2878-6

Electronic_ISBN

978-1-4244-2879-3

Type

conf

DOI

10.1109/BIOCAS.2008.4696949

Filename

4696949