Title :
An Analysis of Non-Coding RNA Using Z-Curve Method
Author :
Yang, Yan-ling ; Wang, Ji-Hua ; Yu, Jia-Feng ; Liu, Gui-zhong
Author_Institution :
Key Lab. of Biophys., Univ. of Shandong, Dezhou
Abstract :
It has very important significance to research non- coding region and its function. The Z curve is a very usefui method for visuaiizing and anaiyzing DNA sequences. It is a three-dimensionai space curve constituting the unique representation of a given DNA sequence in the sense that each can be uniquely reconstructed from the other. Based on the Z curve, a new non-coding RNA-flnding method for some disease- related ncRNAs has been proposed. We select two different types of Specific ncRNAs~BC200 RNA and H19 RNA from the NONCODE database, which relate with diseases Alzheimer and Beckwith-Wiedemann Syndrome,respectively.The corresponding Z curves of the ncRNAs sequences have some special geometrical features. These features can be regard as a criterion to recognize different disease-related ncRNAs.
Keywords :
DNA; cellular biophysics; diseases; molecular biophysics; Alzheimer diseases; Beckwith-Wiedemann syndrome; DNA sequences; Z-curve method; disease- related ncRNA; noncoding RNA; Alzheimer´s disease; Bioinformatics; DNA; Genomics; Humans; Organisms; Proteins; RNA; Sequences; Spatial databases;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.37
