Title :
A New Application of Biclustering Analysis on Loss of Heterozygosity Data of Lung Carcinomas Samples
Author :
Liu, Lisha ; Lian, Zhichao ; Zhang, Jian ; Liang, Yanchun ; Zhou, Chunguang ; Hu, Chengquan
Author_Institution :
Coll. of Comput. Sci. & Technol., Jilin Univ., Changchun
Abstract :
This paper presents a novel efficient method to find submatrices in Loss of Heterozygosity (LOH) data that represent the relationship between specific SNPs loci and particular types of lung cancer. The approach is shown to perform well by experimental results with the SNPs data of 113 samples consisting of 12 normal persons and 101 lung cancer patients. The analyses on results testified the effectiveness and accuracy of the method in discovering chromosome segments related to suppressor genes of lung cancer.
Keywords :
cancer; genetics; lung; medical computing; pattern clustering; pneumodynamics; tumours; biclustering analysis; chromosome; gene suppressor; heterozygosity; lung cancer; lung carcinoma; single nucleotide polymorphism; Bioinformatics; Biological cells; Cancer; Clustering algorithms; Genetic mutations; Genomics; Humans; Lungs; Malignant tumors; Neoplasms;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.181
