Title :
Noise consideration for cancer marker detection using nanowire
Author :
Taiuk Rim ; Sungho Kim ; Kihyun Kim ; Nanki Hong ; Jeong-Soo Lee ; Yoon-Ha Jeong ; Meyyappan, M. ; Chang-Ki Baek
Author_Institution :
Dept. of Creative IT Eng. & the POSTECH Future IT Innovation Lab., Pohang Univ. of Sci. & Technol., Pohang, South Korea
Abstract :
In this paper, a method to extract the signal-to-noise ratio (SNR) is proposed for the Si nanowire (Si-NW) biologically-active field-effect transistors (BioFETs). We have fabricated the devices using CMOS compatible process and demonstrated specific alpha fetoprotein (AFP) detection using the monoclonal antibody of AFP. The low-frequency noise was measured to calculate the parameter. Using our method, we calculated the noise equivalent voltage and calculated the SNR. The Si-NW BioFET showed a SNR of 15.1dB. These parameters are useful indicators to evaluate FET-type sensor devices.
Keywords :
biochemistry; cancer; chemical sensors; field effect transistors; molecular biophysics; nanomedicine; nanowires; noise measurement; patient diagnosis; proteins; silicon; AFP monoclonal antibody; CMOS compatible process; FET-type sensor device evaluation; Si; cancer marker detection; gain 15.1 dB; low-frequency noise measurement; noise equivalent voltage calculation; signal-to-noise ratio extraction; silicon nanowire biologically-active field-effect transistors; specific alpha fetoprotein detection; Logic gates; Nanobioscience; Semiconductor device measurement; Sensitivity; Signal to noise ratio; Silicon;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2014 IEEE 14th International Conference on
Conference_Location :
Toronto, ON
DOI :
10.1109/NANO.2014.6968009
