Title :
Preparation and Anticoagulant Activity of Sulfated 6-Carboxychitosan
Author :
Yang, Yuedong ; Zhou, Yongguo ; Hou, Wenlong ; Zhao, Yongguang ; Ren, Yanjun
Author_Institution :
Dept. of Chem., Hebei Normal Univ. of Sci. & Technol., Qinhuangdao
Abstract :
6-Carboxychitosan (6-CC), prepared by selectively oxidization of chitosan powder with NO2 gas in glacial acetic acid, was sulfated with chlorosulfoni acid in formamide to give sulfated 6-carboxylchitosan (S6CC). In S6CC, -SO3H groups were primarily grafted on -NH2, next on secondary -OH, and thirdly on -CH2OH positions. Sodium salt of S6CC (Na-S6CC) was more similar with heparin sodium than sulfated chitosan in both structure and anticoagulation activity.
Keywords :
biomedical materials; blood; materials preparation; organic compounds; anticoagulant activity; blood coagulant factors; chitosan powder; chlorosulfoni acid; formamide; glacial acetic acid; grafting; hemolytic property; heparin sodium; oxidization; sodium salt; sulfated 6-carboxychitosan; Blood; Chemical technology; Chemistry; Ethanol; Government; Ice; Infrared spectra; Powders; Spectroscopy; Temperature;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.241
