The Effect of ATP and P2X Receptor on Respiration in the Neunatal Rat Transverse Medullary Slice

Author

Ning, Sui ; Ma, Yan ; Song, Na-Na ; Liu, Zi-Bing ; Li, Li ; Zhu, Da-Nian ; Shen, Lin-Lin

Author_Institution

Dept. of Physiol., Fudan Univ., Shanghai

fYear

2008

Firstpage

1054

Lastpage

1057

Abstract

ATP has become widely recognized as a key mediator in both central and peripheral chemosensory transduction in adult rat. The distribution of P2X receptor subtype and the role of ATP in neonatal rat are unclear. The main objective of this study was to observe the role of ATP-mediated respiratory activity in the neonatal rat transverse medullary slice. The increase of respiratory activity was dose-dependent of ATP and via P2X receptors in the medulla of neonatal SD rats. The effect of ATP was reduced by P2X receptor blocker, Suramin or NF279. The inhibition of ATP-excited respiratory activity by NF279 appeared to be more significant than by Suramin.

Keywords

chemioception; neurophysiology; organic compounds; pneumodynamics; ATP dose dependent respiratory activity; ATP effects; ATP mediated respiratory activity; NF279; P2X receptor effects; Suramin; central chemosensory transduction; neonatal rat transverse medullary slice; peripheral chemosensory transduction; respiration; Centralized control; Control systems; Educational institutions; Extracellular; Heart; Immune system; Neurons; Pediatrics; Physiology; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.258

Filename

4535138