DocumentCode
165687
Title
Development of a microfluidic perfusion system for patch clamp recording
Author
Runhuai Yang ; Lai, King W. C. ; Ning Xi ; Jie Yang
Author_Institution
Dept. of Mech. & Biomed. Eng., City Univ. of Hong Kong, Hong Kong, China
fYear
2014
fDate
18-21 Aug. 2014
Firstpage
756
Lastpage
759
Abstract
In this paper, the design of a microfluidic perfusion system for patch clamp recording is reported. The microfluidic perfusion system mainly consists of a polydimethylsiloxane (PDMS) chamber and a micro drug delivery pipette. The performance of the perfusion system was verified by conducting patch clamp recording of neuroblastoma cells. This system provides a method to precisely perform drug delivery without any disturbance of the seal condition.
Keywords
bioMEMS; cellular transport; drug delivery systems; microfluidics; polymers; PDMS; microdrug delivery pipette; microfluidic perfusion system design; neuroblastoma cells; patch clamp recording; perfusion system performance; polydimethylsiloxane chamber; seal condition; Clamps; Drug delivery; Drugs; Extracellular; Glass; Microfluidics; Seals;
fLanguage
English
Publisher
ieee
Conference_Titel
Nanotechnology (IEEE-NANO), 2014 IEEE 14th International Conference on
Conference_Location
Toronto, ON
Type
conf
DOI
10.1109/NANO.2014.6968092
Filename
6968092
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