The Effects of TDI on Mice Marrow Cells

Author

Ji Yubin ; Ji Chenfeng ; Lang, Lang ; Yu Lei ; Zou Xiang

Author_Institution

Center of R&D on Life Sci. & Environ. Sci., Harbin Univ. of Commerce, Harbin

fYear

2008

Firstpage

4570

Lastpage

4572

Abstract

This paper is to study the effects of TDI on mice marrow cells . The effects of TDI were studied by laser scanning confocal microscope to investigate morphologic changing of the mice bone marrow cell and genotoxicity test -chromosomal aberration test and sister chromatic exchange (SCE) test. Results showed that the 1/16LC₅₀ and 1/8LC₅₀ dosage of TDI had no significant effects on the fluorescence pixels rate of RNA/DNA, the chromosome aberration rate and the frequencies of sister chromatic exchange of the mice (P>0.05), but both 1/4 LC₅₀and 1/2 LC₅₀ dosage had significant effects on the fluorescence pixels of RNA/DNA, and the chromosome aberration rate and the frequencies of sister chromatic exchange of the mice (P<0.01). TDI has the genetic toxicity.

Keywords

DNA; biochemistry; biohazards; bone; cellular biophysics; chemical hazards; fluorescence; genetics; industrial pollution; molecular biophysics; optical microscopes; organic compounds; toxicology; DNA; RNA; cell morphology; chromosome aberration rate; fluorescence pixels rate; genetic toxicity; genotoxicity test -chromosomal aberration test; laser scanning confocal microscope; mice bone marrow cell; sister chromatic exchange test; toluene diisocyanate effects; Biological cells; Bones; Cells (biology); DNA; Fluorescence; Frequency; Mice; Microscopy; RNA; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.302

Filename

4535182