Title :
Polyacrylic acid-derivatized superparamagnetic iron oxide nanoparticles for delivery of tissue plasminogen activator
Author :
Chen, Jyh-Ping ; Yang, Pei-Chin ; Hwang, Hwei-Fang
Author_Institution :
Dept. of Chem. & Mater. Eng., Chang Gung Univ., Taoyuan, Taiwan
Abstract :
Polyacrylic acid (PAA)-derivatized Fe3O4 magnetic nanoparticle (MNP) intended as a drug carrier were synthesized by two different approaches and studied for chemicophysical properties. PAA-MNP prepared by physical adsorption of PAA on pre-formed MNP showed better properties for covalent binding with a thrombolytic drug, recombinant tissue plasminogen activator (rtPA). The PAA-MNP-rtPA conjugate showed full retention of thrombolytic activity and is useful as a magnetically targeted drug carrier to improve clinical thrombolytic therapy.
Keywords :
adsorption; biochemistry; biological tissues; biomedical materials; drugs; iron compounds; magnetic particles; nanobiotechnology; nanoparticles; superparamagnetism; Fe3O4; chemicophysical properties; clinical therapy; covalent binding; magnetic nanoparticle; physical adsorption; polyacrylic acid; recombinant tissue plasminogen activator; superparamagnetic iron oxide; thrombolytic drug; Design methodology; Drugs; Iron; Medical treatment; Morphology; Nanoparticles; Radiative recombination; SQUIDs; Spontaneous emission; Superconducting magnets;
Conference_Titel :
Nanoelectronics Conference (INEC), 2010 3rd International
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-3543-2
Electronic_ISBN :
978-1-4244-3544-9
DOI :
10.1109/INEC.2010.5424830
