Preparation of composite electrospun nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiation of stem cells

Author

Chen, Jyh-Ping ; Lai, Guo-Chun ; Chang, Yin-Shin

Author_Institution

Dept. of Chem. & Mater. Eng., Chang Gung Univ., Taoyuan, Taiwan

fYear

2010

Firstpage

1395

Lastpage

1396

Abstract

Nanocomposites of poly(Â¿-caprolactone) (PCL) and nanohydroxyapatite (nHAP) were prepared by electrospinning to produce 300 nm nanofibers containing 0, 25, and 50 wt% of nHAP. The composite nanofibers were characterized for structure, morphology, and mechanical properties. Mesenchymal stem cells grown on the nanofibers show different degree of osteogenic differentiation dependent on nHAP content with the highest nHAP content giving the best mineralization.

Keywords

biomedical materials; bone; calcium compounds; cellular biophysics; electrospinning; nanobiotechnology; nanocomposites; nanofibres; organic compounds; tissue engineering; composite nanofibers; electrospinning; mesenchymal stem cells; nanocomposites; nanoflbers; nanohydroxyapatite; osteogenic differentiation; poly(Â¿-caprolactone); Bones; Mechanical factors; Mineralization; Morphology; Nanobioscience; Polymers; Scanning electron microscopy; Solvents; Stem cells; Temperature control;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanoelectronics Conference (INEC), 2010 3rd International

Conference_Location

Hong Kong

Print_ISBN

978-1-4244-3543-2

Electronic_ISBN

978-1-4244-3544-9

Type

conf

DOI

10.1109/INEC.2010.5424832

Filename

5424832