Title :
Preparation of composite electrospun nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiation of stem cells
Author :
Chen, Jyh-Ping ; Lai, Guo-Chun ; Chang, Yin-Shin
Author_Institution :
Dept. of Chem. & Mater. Eng., Chang Gung Univ., Taoyuan, Taiwan
Abstract :
Nanocomposites of poly(¿-caprolactone) (PCL) and nanohydroxyapatite (nHAP) were prepared by electrospinning to produce 300 nm nanofibers containing 0, 25, and 50 wt% of nHAP. The composite nanofibers were characterized for structure, morphology, and mechanical properties. Mesenchymal stem cells grown on the nanofibers show different degree of osteogenic differentiation dependent on nHAP content with the highest nHAP content giving the best mineralization.
Keywords :
biomedical materials; bone; calcium compounds; cellular biophysics; electrospinning; nanobiotechnology; nanocomposites; nanofibres; organic compounds; tissue engineering; composite nanofibers; electrospinning; mesenchymal stem cells; nanocomposites; nanoflbers; nanohydroxyapatite; osteogenic differentiation; poly(¿-caprolactone); Bones; Mechanical factors; Mineralization; Morphology; Nanobioscience; Polymers; Scanning electron microscopy; Solvents; Stem cells; Temperature control;
Conference_Titel :
Nanoelectronics Conference (INEC), 2010 3rd International
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-3543-2
Electronic_ISBN :
978-1-4244-3544-9
DOI :
10.1109/INEC.2010.5424832
