Effects of Puerarin on Monoamino Neurotransmitter Levels in the Striatum of Cerebral Ischemia Rats

Author

Li Hui ; Zheng Xiaoxiang

Author_Institution

Coll. of Biomed. Eng. & Instrum. Sci., Zhejiang Univ., Hangzhou

fYear

2008

Firstpage

1332

Lastpage

1335

Abstract

This study was undertaken to examine the patterns of changes in extracellular fluid (ECF) dopamine (DA), orepinephrine (NE) and serotonin (5-HT) in the striatum of rats with middle cerebral artery occlusion (MCAO). The effect of Puerarin on monoamine neurotransmitter in the MCAO rats was also studied. Methods: Microdialysis was used to sample the brains extracellular space during 80 min of cerebral ischemia followed by 80 min of reperfusion. The microdialysate was measured by high performed liquid chromatography (HPLC). Results: It showed Puerarin could alleviate cerebral ischemia damage.

Keywords

biochemistry; brain; neurophysiology; Puerarin; cerebral ischemia; dopamine; extracellular fluid; liquid chromatography; microdialysis; middle cerebral artery occlusion; monoamino neurotransmitter levels; orepinephrine; rats; serotonin; striatum; Animals; Arterial occlusion; Carotid arteries; Extracellular; Independent component analysis; Ischemic pain; Neurons; Neurotransmitters; Rats; Surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.662

Filename

4535542