Title :
Effects of Puerarin on Monoamino Neurotransmitter Levels in the Striatum of Cerebral Ischemia Rats
Author :
Li Hui ; Zheng Xiaoxiang
Author_Institution :
Coll. of Biomed. Eng. & Instrum. Sci., Zhejiang Univ., Hangzhou
Abstract :
This study was undertaken to examine the patterns of changes in extracellular fluid (ECF) dopamine (DA), orepinephrine (NE) and serotonin (5-HT) in the striatum of rats with middle cerebral artery occlusion (MCAO). The effect of Puerarin on monoamine neurotransmitter in the MCAO rats was also studied. Methods: Microdialysis was used to sample the brains extracellular space during 80 min of cerebral ischemia followed by 80 min of reperfusion. The microdialysate was measured by high performed liquid chromatography (HPLC). Results: It showed Puerarin could alleviate cerebral ischemia damage.
Keywords :
biochemistry; brain; neurophysiology; Puerarin; cerebral ischemia; dopamine; extracellular fluid; liquid chromatography; microdialysis; middle cerebral artery occlusion; monoamino neurotransmitter levels; orepinephrine; rats; serotonin; striatum; Animals; Arterial occlusion; Carotid arteries; Extracellular; Independent component analysis; Ischemic pain; Neurons; Neurotransmitters; Rats; Surgery;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.662
