Preparation, Sustained-Release and Transdermal Penetration Properties of Drug-Loaded Hollow Fibers

Author

Zhu, S.J. ; Yu, D.G. ; Zhu, L.M. ; Branford-White, C.

Author_Institution

Chem. Eng. & Biotechnol., Donghua Univ., Shanghai

fYear

2008

Firstpage

1379

Lastpage

1382

Abstract

Acyclovir-loaded PAN hollow fibers were prepared with dry-wet spinning processes. The co- blendine method was employed to prepare the spinning liquid. The prepared hollow fibers had a diameter 01 300 mum. The drug content in the hollow fibers is lower than that in the spinning liquid, 20.28% of the drug was lost during the spinning processes. SIn vitro dissolution tests indicated the obvious initial burst effect. Permeability test results illustrated that the permeation of acyclovir is limited by the skin.

Keywords

biomedical materials; drug delivery systems; drugs; permeability; polymer fibres; skin; acyclovir-loaded PAN hollow fibers; drug preparation; drug-loaded hollow fibers; dry-wet spinning process; in vitro dissolution; initial burst effect; permeability; sustained drug release; transdermal penetration; Biological materials; Biomedical materials; Coagulation; Drug delivery; Gastrointestinal tract; Liquids; Liver; Optical fiber testing; Powders; Spinning;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.674

Filename

4535554