Title :
Preparation, Sustained-Release and Transdermal Penetration Properties of Drug-Loaded Hollow Fibers
Author :
Zhu, S.J. ; Yu, D.G. ; Zhu, L.M. ; Branford-White, C.
Author_Institution :
Chem. Eng. & Biotechnol., Donghua Univ., Shanghai
Abstract :
Acyclovir-loaded PAN hollow fibers were prepared with dry-wet spinning processes. The co- blendine method was employed to prepare the spinning liquid. The prepared hollow fibers had a diameter 01 300 mum. The drug content in the hollow fibers is lower than that in the spinning liquid, 20.28% of the drug was lost during the spinning processes. SIn vitro dissolution tests indicated the obvious initial burst effect. Permeability test results illustrated that the permeation of acyclovir is limited by the skin.
Keywords :
biomedical materials; drug delivery systems; drugs; permeability; polymer fibres; skin; acyclovir-loaded PAN hollow fibers; drug preparation; drug-loaded hollow fibers; dry-wet spinning process; in vitro dissolution; initial burst effect; permeability; sustained drug release; transdermal penetration; Biological materials; Biomedical materials; Coagulation; Drug delivery; Gastrointestinal tract; Liquids; Liver; Optical fiber testing; Powders; Spinning;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.674
