Title :
Fabrication and Characterization of Electrospun Poly(L-Lactic Acid)and Poly(L-Lactide-Co-Glycolide) Mats as Wound Dressing
Author :
Gu, Shuying ; Wang, Zhimei ; Ren, Jie ; Zhang, Chunyan
Author_Institution :
Sch. of Mater. Sci. & Eng., Tongji Univ., Shanghai
Abstract :
Electrospun poly (L-lactic acid) (PLLA) and poly (L-lactide -co -glycolide) (PLGA) mats were fabricated as wound dressings. The in vitro degradation behavior was studied in phosphate buffer solution (PBS, pH 7.4) at 37degC for 6 days. Structural and morphological changes during degradation were investigated with gel permeation chromatography (GPC) and scanning electron microscopy (SEM). Both of the electrospun biopolymer mats showed stable degradation rate without losing the fibrous structure. Water adsorption ability, water retention ability and water vapor permeability were monitored comparing with PLGA casting film. The results indicates that the electrospun PLLA and PLGA mats are suitable for wound dressing and PLGA mat is more preferable.
Keywords :
adsorption; biomedical materials; chromatography; polymers; scanning electron microscopy; biopolymer mats; degradation; electrospun poly (L-lactic acid); gel permeation chromatography; mat characterization; mat fabrication; morphological changes; poly (L-lactide -co -glycolide); scanning electron microscopy; structural changes; temperature 37 degC; time 6 day; water adsorption ability; water retention ability; water vapor permeability; wound dressings; Biological materials; Degradation; Fabrication; Humans; In vitro; Materials science and technology; Permeability; Protection; Scanning electron microscopy; Wounds;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.708
