Different Approaches for Detecting Glucose

The component technology of optoelectronics has shown rapid progress after the discovery of the laser. Nowadays the development of components is led by telecommunications. Reliable light source and detector components, together with optical fibers and new manufacturing technologies, give potential to applications of optoelectronics. The first method which can be mention is a micro fluidic lab-on-a-chip (LoC) platform for in vitro measurement of glucose for clinical diagnostic applications. The LoC uses a discrete droplet format in contrast to conventional continuous flow microfluidic systems. The droplets act as solution-phase reaction chambers and are manipulated using the electrowetting effect. Glucose is measured using a colorimetric enzyme-kinetic method based on Trinder´s reaction. The second one is an increasing number of recent studies have shown that interstitial fluid (ISF) can serve as a reliable surrogate for blood in the measurement of physiological glucose. This opens the exciting possibility of developing lesser invasive methods for measuring glucose continuously over extended time periods in diabetic individuals. We describe here a system under development at SpectRx, Inc. (Norcross, GA) that accesses, acquires and measures glucose in ISF The ultimate goal and potential of this development effort is the replacement of finger stick blood glucose testing with an affordable and convenient system that provides an accurate glucose reading every 5 minutes with alarms for trends toward hypoglycemic and hyperglycemic events. The third one is, Laser Light Scattering Spectroscopy of In Vivo Human Lenses. Laser light scattering spectroscopy measures the thermal random movement of protein as characterized by the diffusion coefficient