Title :
Performance evaluation of a tiny insect muscle-powered bioactuator using gene modified Drosophila melanogaster´s dorsal vessel tissue
Author :
Suzumura, Kiyofumi ; Takizawa, Kensuke ; Tsujimura, Hidenobu ; Iwabuchi, Kikuo ; Hoshino, Takayuki ; Morishima, Keisuke
Author_Institution :
Dept. of Bio-Applic. & Syst. Eng., Tokyo Univ. of Agric. & Technol., Koganei, Japan
Abstract :
We propose a novel bio-actuator powered Drosophila melanogaster´s dorsal vessel. Insect cells are robust over a range of culture conditions compared mammalian cells. Therefore, micro-actuator powered D.melanogaster´s dorsal vessel can be driven without precise environmental control. D.melanogaster is also well known to a model organism in genetic engineering, so its gene information has been achieved so far. Over the past a few decades, adoption and refinement of the GAL4 system by Drosophila field has resulted in a wide array of tool. So, we can control Bio-actuator´s movement by using genetically modified D.melanogaster´s dorsal vessel tissue. In this study, beating frequency and beating force of Wild-type dorsal vessels were measured to evaluate their performance. Their results showed the possibility of the bio-actuator powered by dorsal D.melanogaster´s dorsal vessel.
Keywords :
bioMEMS; biological specimen preparation; cellular biophysics; genetic engineering; microactuators; muscle; optical tomography; performance evaluation; zoology; Drosophila melanogaster dorsal vessel; GAL4 system; beating force; beating frequency; bioactuators movement; gene information; gene modification; genetic engineering; insect cells; mammalian cells; microactuator; performance evaluation; tiny insect muscle-powered bioactuator; wild-type dorsal vessels; Cardiology; Genetics;
Conference_Titel :
Micro-NanoMechatronics and Human Science (MHS), 2010 International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4244-7995-5
DOI :
10.1109/MHS.2010.5669558