High precision magnetically driven microtools with ultrasonic vibration for enucleation of oocytes

This paper presents innovative driving method for the magnetically driven microtools (MMT) which is micrometer positioning accuracy by horizontally arranged permanent magnets. A piezoelectric ceramic is used to induce nanoscale vibration to the microfluidic chip to reduce the friction on the MMT. The enucleation process has been conducted by the dual arm MMTs. MMTs receive enough driving power supplied by permanent magnets and their positioning accuracy is adequate to cut oocytes precisely. It takes only 5 seconds to cut the nucleus and the removed area is less than 25 percent of the original oocyte.