New Target Controlled Infusion Using a Hybrid Physiologically Based Pharmacokinetic Model

Author

Wang, Xuan ; Pan, Yi ; Chen, Hang ; Ye, Shuming ; Chen, Xinzhong

Author_Institution

Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou

fYear

2008

Firstpage

1822

Lastpage

1824

Abstract

New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The hybrid model was composed of a three-compartment mamillary systemic model and a two-compartment brain model. A closed-loop control algorithm with brain concentration as the control variable was used to calculate the infusion. Finally, the dose regimen was applied in clinical practice and the recorded auditory evoked potentials showed good depth of anaesthesia. The TCI was feasible and had potential applications.

Keywords

auditory evoked potentials; biochemistry; brain models; closed loop systems; drugs; medical computing; medical control systems; neurophysiology; anaesthesia depth; auditory evoked potentials; brain concentration; closed-loop control algorithm; computerized infusion technique; hybrid physiologically based pharmacokinetic model; propofol; target controlled infusion; three-compartment mamillary systemic model; two-compartment brain model; Anesthesia; Biomedical engineering; Brain modeling; Centralized control; Drugs; Hospitals; Integrated circuit modeling; Mathematical model; Plasmas; Three-term control;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-1747-6

Electronic_ISBN

978-1-4244-1748-3

Type

conf

DOI

10.1109/ICBBE.2008.784

Filename

4535664