Title :
New Target Controlled Infusion Using a Hybrid Physiologically Based Pharmacokinetic Model
Author :
Wang, Xuan ; Pan, Yi ; Chen, Hang ; Ye, Shuming ; Chen, Xinzhong
Author_Institution :
Dept. of Biomed. Eng., Zhejiang Univ., Hangzhou
Abstract :
New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The hybrid model was composed of a three-compartment mamillary systemic model and a two-compartment brain model. A closed-loop control algorithm with brain concentration as the control variable was used to calculate the infusion. Finally, the dose regimen was applied in clinical practice and the recorded auditory evoked potentials showed good depth of anaesthesia. The TCI was feasible and had potential applications.
Keywords :
auditory evoked potentials; biochemistry; brain models; closed loop systems; drugs; medical computing; medical control systems; neurophysiology; anaesthesia depth; auditory evoked potentials; brain concentration; closed-loop control algorithm; computerized infusion technique; hybrid physiologically based pharmacokinetic model; propofol; target controlled infusion; three-compartment mamillary systemic model; two-compartment brain model; Anesthesia; Biomedical engineering; Brain modeling; Centralized control; Drugs; Hospitals; Integrated circuit modeling; Mathematical model; Plasmas; Three-term control;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.784
