Title :
Biomechanical Properties of Experimental Myopia in the Guinea Pig
Author :
Wang Xiaojun ; Chen Weiyi ; Li Yanjun ; Gao Tieying
Author_Institution :
Appl. Mech. Inst., TUT, Taiyuan
Abstract :
A lens induce myopia model in 12 healthy guinea pigs was used in this study. For each guinea pig, one eye was selected randomly for myopia model, another served as a paired control. After 45 days, eye became myopic and elongated in myopia model. The alteration of eye volume with intraocular pressure was determined. Cornea and sclera strips were prepared for biomechanical properties measurement through uniaxial tension using Instron 5544 test machine. Our results showed that the ocular rigidity coefficient of myopia model eyeballs was lower than the control ones. Furthermore, under the physiological eye pressure, the elastic modulus of either sclera or cornea decreased significantly as compared to control ones. The ANSYS finite element simulation also confirmed that the maximal shape deformation of eyeball occurred in the polar of the post sclera and the maximal strain in the myopia model eyes was higher than the control ones.
Keywords :
biology computing; biomechanics; elastic moduli; eye; finite element analysis; physiological models; vision defects; ANSYS finite element simulation; Instron 5544 test machine; cornea; elastic modulus; eye; guinea pig; intraocular pressure; lens induce myopia model; ocular rigidity coefficient; sclera strips; time 45 day; uniaxial tension; Capacitive sensors; Cornea; Deformable models; Eyes; Finite element methods; Lenses; Pressure control; Shape control; Strips; Testing;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.785
