Role of Ca-activated Cl currents in the heart: a computer model

Author

Gomis-Tena, J. ; Saiz, J.

Author_Institution

Lab. Integrado de Bioingenieria, Univ. Politecnica de Valencia, Spain

fYear

1999

fDate

6/21/1905 12:00:00 AM

Firstpage

109

Lastpage

112

Abstract

Shows a new mathematical model for the cardiac Ca-dependent chloride current (I_Cl,Ca). This model has been introduced in the Lindblad et al. (1996) model of rabbit atrial cell (LMCG model), and it is used to test the role of this current in normal and pathological situations. For normal situations, I_Cl,Ca is the second component of a transient outward current (I_to) and results show that it is responsible for action potential duration (APD) regulation at high rates. In pathological conditions which provoke Early After Depolarizations (EAD) results show that I_Cl,Ca avoids EAD generation. The hypothesis reported in the literature about the possibility of I_Cl,Ca being a component of a transient inward current that provokes Delayed After Depolarizations (DAD) is also confirmed

Keywords

bioelectric phenomena; biology computing; calcium; cardiology; chlorine; digital simulation; physiological models; Ca; Ca-activated Cl currents role; Cl; action potential duration regulation; cardiac electrophysiology; computer model; delayed after depolarizations; heart; transient inward current; transient outward current; Calcium; Delay; Equations; Heart; Integrated circuit modeling; Mathematical model; Rabbits; Shape; Testing; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology, 1999

Conference_Location

Hannover

ISSN

0276-6547

Print_ISBN

0-7803-5614-4

Type

conf

DOI

10.1109/CIC.1999.825918

Filename

825918