Title :
Study of the mechanisms of arrhythmias in an anatomical computer model of human atria
Author :
Virag, N. ; Blanc, O. ; Vesin, J.-M. ; Koerfer, J. ; Kappenberger, L.
Author_Institution :
Signal Process. Lab., Swiss Fed. Inst. of Technol., Lausanne, Switzerland
fDate :
6/21/1905 12:00:00 AM
Abstract :
Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and embolism. Based on a 20 heterogeneous and anisotropic model of cardiac tissue using the Beeler-Reuter and the Luo-Rudy models, a realistic 30 anatomical computer model of human atria containing about 250000 cardiac cells has been designed. The simulated size is 3 cm×3 cm×7 cm and holes of appropriate size have been placed for the veins and the valves. Using a programmed stimulation protocol similar to those of clinical electrophysiological studies, sustained atrial flutter with a periodic pattern has been induced as well as atrial fibrillation with a random pattern containing up to 6 independent wavelets. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing details difficult to study in nature and of being reproducible
Keywords :
bioelectric phenomena; cardiology; cellular biophysics; digital simulation; medical computing; physiological models; 3 cm; 7 cm; Beeler-Reuter model; Luo-Rudy model; anatomical computer model; cardiac arrhythmias mechanisms; cardiac electrophysiology; discomfort; embolism; heart failure; heterogeneous anisotropic cardiac tissue model; human atria; valves; veins; Anisotropic magnetoresistance; Biomembranes; Cardiac tissue; Cardiology; Computational modeling; Computer simulation; Conductivity; Heart; Humans; Solid modeling;
Conference_Titel :
Computers in Cardiology, 1999
Conference_Location :
Hannover
Print_ISBN :
0-7803-5614-4
DOI :
10.1109/CIC.1999.825919
