Title :
Measuring the Similarity of Co-Regulated Genes by Integrating Quantity and Tendency of Gene Expression Changing
Author :
Wang, Han ; Zhou, Chunguang ; Ming Zheng ; Shanhong Zheng ; Guixia Liu ; Lei Liu ; Li, Yanwen
Author_Institution :
Coll. of Comput. Sci. & Technol., Jilin Univ., Changchun
Abstract :
This paper defines a new correlation coefficient SMBS which using both quantity and tendency in gene expression changing to measure the similarity among genes. The SMBS applies to K-means clustering algorithm and the result shows more co-regulated genes are found comparing with the CLUSTER3.0.
Keywords :
DNA; arrays; biochemistry; biology computing; genetics; molecular biophysics; pattern clustering; statistical analysis; DNA microarray technologies; K-means clustering algorithm; co-regulated genes similarity; correlation coefficient SMBS; gene expression quantity; gene expression tendency; Clustering algorithms; Computer science; Distance measurement; Educational institutions; Euclidean distance; Fungi; Gene expression; Paper technology; Regulators; Testing;
Conference_Titel :
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-1747-6
Electronic_ISBN :
978-1-4244-1748-3
DOI :
10.1109/ICBBE.2008.803
