Title :
Spectrally multiplexed photothermal OCT and novel detection methods
Author :
Kim, Sanghoon ; Rinehart, Matthew T. ; Zhu, Yizheng ; Wax, Adam
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
We demonstrate simultaneous detection of two nanoparticle species using phase-sensitive optical coherence tomography with photothermal excitation at two wavelengths matched to the distinct absorption peaks of the nanoparticles. To minimize bulk heating of the sample, a novel single-pulse excitation scheme is proposed and its sensitivity is characterized.
Keywords :
biomedical optical imaging; biothermics; gold; heating; nanomedicine; nanoparticles; optical tomography; photothermal effects; silver; Ag; Au; gold nanoparticles; heating; novel detection method; novel single-pulse excitation scheme; phase-sensitive optical coherence tomography; photothermal excitation; silver nanoparticles; spectrally multiplexed photothermal OCT; Gold; Heating; Nanoparticles; Optical imaging; Optical sensors; Phase measurement; Signal to noise ratio;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2012 Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4673-1839-6
